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Police Detective Sgt. Joe Friday and his partners investigate crimes in Los Angeles.
Friday begins to question Henry Ross, a suspect in a man's disappearance, which Friday believes is actually a murder. Ross coolly and calmly denies any involvement in the disappearance, but Friday's relentless interrogation soon begin to crack the man's facade.
Friday and Jacobs question a jeweler regarding the robbery of a colleague. The man takes offense at being questioned about the incident, but as the detectives begin to amass evidence, the jeweler's outrage quickly begins to lose credibility.
Friday and Jacobs are called to the apartment of a man who phoned in the fatal shooting of his wife. He claims it was suicide, but upon looking at the crime scene and talking to neighbors they begin to wonder if it was murder.
A burglar has an airtight case against him and the judge tells the jury that found him not guilty it was a travesty of justice.
A holdup man is sticking up bars. After he takes the money he kills many of his victims. Sargeant Friday has few leads other than that the holdup man likes a certain song on the jukebox and likes to drink scotch and water.